About Help FAQ

Symbol
Name
ID

Stx11
syntaxin 11
MGI:1921982

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Neutropenia	Hemophagocytosis	Conjunctivitis	Lymphadenopathy	Splenomegaly	Skin rash
Disease(s) Associated with STX11
familial hemophagocytic lymphohistiocytosis 4

Mouse Phenotypes

decreased NK cell degranulation

decreased neutrophil cell number

increased lymphocyte cell number

decreased leukocyte cell number

abnormal neutrophil physiology

abnormal lymphocyte physiology

impaired natural killer cell mediated cytotoxicity

abnormal cytotoxic T cell physiology

decreased cytotoxic T cell cytolysis

increased circulating interferon-gamma level

increased circulating interleukin-1 beta level

increased circulating interleukin-6 level

increased circulating tumor necrosis factor level

abnormal cell-mediated immunity

abnormal cytokine secretion

increased interferon-gamma secretion

increased tumor necrosis factor secretion

increased susceptibility to Riboviria infection

Availability

Mouse Genotype

Stx11^em1(IMPC)Mbp/Stx11^em1(IMPC)Mbp

Stx11^tm1.2Ics/Stx11^tm1.2Ics

Stx11^tm1Bupa/Stx11^tm1Bupa

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23